Single-Chain Structure of Human Ceruloplasmin
نویسندگان
چکیده
منابع مشابه
Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.
We have determined the amino acid sequence of the amino-terminal 67,000-dalton (67-kDa) fragment of human ceruloplasmin and have established overlapping sequences between the 67-kDa and 50-kDa fragments and between the 50-kDa and 19-kDa fragments. The 67-kDa fragment contains 480 amino acid residues and three glucosamine oligosaccharides. These results together with our previous sequence data f...
متن کاملPrimary structure of single-chain pro-urokinase.
Single-chain pro-urokinase is an inactive proenzyme form of human urokinase with a single-chain structure and a Mr of 50,000 and converted to the active two-chain form by catalytic amounts of plasmin. It was isolated from culture fluid of human kidney cells and subjected to chemical (CNBr) and proteolytic (lysyl endopeptidase) degradation. The resulting peptides were separated by reverse-phase ...
متن کاملinhibition of human ceruloplasmin (ferroxidase) by cadmium
ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...
متن کاملMechanisms of copper incorporation into human ceruloplasmin.
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis. To elucidate the mechanisms of copper incorporation into this protein, holoceruloplasmin biosynthesis was examined by immunoblot analysis and (64)Cu metabolic labeling of Chinese hamster ovary cells transfected with cDNAs encoding wild-type or mutant ceruloplasmin. This analysis reveals that the incorporation of coppe...
متن کاملCrystal structure of a human CD3- dimer in complex with a UCHT1 single-chain antibody fragment
The T cell receptor complex transmits signals from MHC peptide antigens through a set of constitutively associated signaling molecules, including CD3and CD3. We report the crystal structure at 1.9-Å resolution of a complex between a human CD3ectodomain heterodimer and a single-chain fragment of the UCHT1 antibody. CD3and CD3share a conserved interface between the Ig-fold ectodomains, with paral...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1972
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1972.tb01777.x